Pesquisa | BVS IEC

1.

Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control.

Müller, Martin B D; Kasturi, Prasad; Jayaraj, Gopal G; Hartl, F Ulrich.

Cell ; 186(15): 3227-3244.e20, 2023 07 20.

Artigo em Inglês | MEDLINE | ID: mdl-37339632

2.

Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes.

Flecken, Mirkko; Wang, Huping; Popilka, Leonhard; Hartl, F Ulrich; Bracher, Andreas; Hayer-Hartl, Manajit.

Cell ; 183(2): 457-473.e20, 2020 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-32979320

3.

Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC.

Balchin, David; Milicic, Goran; Strauss, Mike; Hayer-Hartl, Manajit; Hartl, F Ulrich.

Cell ; 174(6): 1507-1521.e16, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30100183

4.

GroEL Ring Separation and Exchange in the Chaperonin Reaction.

Yan, Xiao; Shi, Qiaoyun; Bracher, Andreas; Milicic, Goran; Singh, Amit K; Hartl, F Ulrich; Hayer-Hartl, Manajit.

Cell ; 172(3): 605-617.e11, 2018 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-29336887

5.

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

Guo, Qiang; Lehmer, Carina; Martínez-Sánchez, Antonio; Rudack, Till; Beck, Florian; Hartmann, Hannelore; Pérez-Berlanga, Manuela; Frottin, Frédéric; Hipp, Mark S; Hartl, F Ulrich; Edbauer, Dieter; Baumeister, Wolfgang; Fernández-Busnadiego, Rubén.

Cell ; 172(4): 696-705.e12, 2018 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-29398115

6.

Protein Misfolding Diseases.

Hartl, F Ulrich.

Annu Rev Biochem ; 86: 21-26, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28441058

7.

Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis.

Izawa, Toshiaki; Park, Sae-Hun; Zhao, Liang; Hartl, F Ulrich; Neupert, Walter.

Cell ; 171(4): 890-903.e18, 2017 Nov 02.

Artigo em Inglês | MEDLINE | ID: mdl-29107329

8.

In Situ Architecture and Cellular Interactions of PolyQ Inclusions.

Bäuerlein, Felix J B; Saha, Itika; Mishra, Archana; Kalemanov, Maria; Martínez-Sánchez, Antonio; Klein, Rüdiger; Dudanova, Irina; Hipp, Mark S; Hartl, F Ulrich; Baumeister, Wolfgang; Fernández-Busnadiego, Rubén.

Cell ; 171(1): 179-187.e10, 2017 Sep 21.

Artigo em Inglês | MEDLINE | ID: mdl-28890085

9.

Cellular Homeostasis and Aging.

Hartl, F Ulrich.

Annu Rev Biochem ; 85: 1-4, 2016 Jun 02.

Artigo em Inglês | MEDLINE | ID: mdl-27050288

10.

The proteostasis network and its decline in ageing.

Hipp, Mark S; Kasturi, Prasad; Hartl, F Ulrich.

Nat Rev Mol Cell Biol ; 20(7): 421-435, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-30733602

11.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther, Dirk M; Kasturi, Prasad; Zheng, Min; Pinkert, Stefan; Vecchi, Giulia; Ciryam, Prajwal; Morimoto, Richard I; Dobson, Christopher M; Vendruscolo, Michele; Mann, Matthias; Hartl, F Ulrich.

Cell ; 161(4): 919-32, 2015 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-25957690

12.

Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding.

Gropp, Michael H M; Klaips, Courtney L; Hartl, F Ulrich.

Mol Cell ; 82(22): 4290-4306.e11, 2022 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-36272412

13.

Quality Control: Maintaining molecular order and preventing cellular chaos.

Neal, Sonya; Ohtake, Fumiaki; Cuervo, Ana Maria; Hegde, Ramanujan S; Jakob, Ursula; Lazarou, Michael; Gilbert, Wendy V; Chen, Zhijian J; Tooze, Sharon A; Haber, James E; Walters, Kylie J; Hartl, F Ulrich.

Mol Cell ; 82(8): 1390-1397, 2022 04 21.

Artigo em Inglês | MEDLINE | ID: mdl-35452608

14.

Sugarcoating ER Stress.

Vincenz, Lisa; Hartl, F Ulrich.

Cell ; 156(6): 1125-1127, 2014 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-24630714

15.

Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.

Raychaudhuri, Swasti; Loew, Christian; Körner, Roman; Pinkert, Stefan; Theis, Mirko; Hayer-Hartl, Manajit; Buchholz, Frank; Hartl, F Ulrich.

Cell ; 156(5): 975-85, 2014 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-24581496

16.

GroEL/ES chaperonin modulates the mechanism and accelerates the rate of TIM-barrel domain folding.

Georgescauld, Florian; Popova, Kristina; Gupta, Amit J; Bracher, Andreas; Engen, John R; Hayer-Hartl, Manajit; Hartl, F Ulrich.

Cell ; 157(4): 922-934, 2014 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-24813614

17.

A new way of D/Ealing with protein misfolding.

Sitron, Cole S; Hartl, F Ulrich.

Mol Cell ; 81(20): 4114-4115, 2021 10 21.

Artigo em Inglês | MEDLINE | ID: mdl-34686313

18.

Bacterial RF3 senses chaperone function in co-translational folding.

Zhao, Liang; Castanié-Cornet, Marie-Pierre; Kumar, Sneha; Genevaux, Pierre; Hayer-Hartl, Manajit; Hartl, F Ulrich.

Mol Cell ; 81(14): 2914-2928.e7, 2021 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-34107307

19.

Molecular chaperone functions in protein folding and proteostasis.

Kim, Yujin E; Hipp, Mark S; Bracher, Andreas; Hayer-Hartl, Manajit; Hartl, F Ulrich.

Annu Rev Biochem ; 82: 323-55, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23746257

20.

PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone.

Park, Sae-Hun; Kukushkin, Yury; Gupta, Rajat; Chen, Taotao; Konagai, Ayano; Hipp, Mark S; Hayer-Hartl, Manajit; Hartl, F Ulrich.

Cell ; 154(1): 134-45, 2013 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-23791384

BVS IEC

Instituto Evandro Chagas

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